• Yasumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K. : Tumor necrosis factor α and interferon γ synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-κB-like binding sites of the interleukin 8 gene. J Biol Chem 267:22506-11, 1992
• Singh RK, Berry K, Matsushima K, Yasumoto K, Fidler IJ. : Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages. J Immunol 151:2786-93, 1993
• Okamato S, Mukaida N, Yasumoto K, Nancy Rice Ishikawa Y, Horiguchi H, Murakami S, Matsushima K. : The interleukin-8 AP-1 and kB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. J Biol Chem 269:8582-9, 1994
• Yasumoto K, Mukaida N, Harada A, kuno K, Akiyama M, Nakajima E, Fujioka N, Mai M, Kasahara T, Fujimoto-ouchi K, Mori K, Tanaka Y, Matsushima K. : Molecular analysis of the cytokine network involved in cachexia in colon 26 adenocarcinoma-bearing mice. Cancer Res 55:921-7, 1995
• Yasumoto K, Takahashi Y, Mai M, Kawashima A. : Meningeal carcinomatosis preceded by a rapid increase in serum CA19-9 levels in a patient with breast cancer. Int J Clin Oncol 10:276-80, 2005
• Yasumoto K, Kitakata H, Yamashita K, Omote K, Takahashi Y. : Combination chemotherapy of TS-1, Docetaxel and CDDP produces a remarkable response in a patient with advanced esophageal cancer. Jpn J Cancer Chemother 33: 965-967, 2006
• Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I. Role of the CXCL12/ CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 2006; 66:2181-7.
• Shakoori A, Mai W, Miyashita K, Yasumoto K, Takahashi Y, Ooi A, Kawakami K, Minamoto T. : Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci 98:1388-93, 2007
• Kitakata H, Yasumoto K*, Sudo Y, Minato H, Takahashi Y. : A case of primary small cell carcinoma of the breast. Breast Cancer 14:414-9, 2007
• Koizumi K, Hojo S, Akashi T, Yasumoto K, Saiki I. : Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response. Cancer Sci 98:1652-8, 2007
• Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S. : The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res 17:3619-30, 2011
• Li Q, Wang W, Yamada T, Matsumoto K, Sakai K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yasumoto K, Yano S. : Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network. Am J Pathol 179:1483-93, 2011
• Ohtsubo K, Watanabe H, Mouri H, Yamashita K, Yasumoto K, Yano S : Endoscopic findings of upper gastrointestinal lesions in patients with pancreatic cancer. JOP 13:420-6, 2012
• Ishikawa D, Takeuchi S, Nakagawa T, Sano T, Nakade J, Nanjo S, Yamada T, Ebi H, Zhao L, Yasumoto K, Nakamura T, Matsumoto K, Kagamu H, Yoshizawa H, Yano S. : mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF. PLoS One 8:e62104, 2013
• Zhao, L, Yasumoto, K*, Kawashima A, Nakagawa T, Takeuchi S, Yamada T, Matsumoto K, Yonekura K, Yoshie O, Yano, S. : Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer. Cancer Sci 104:1640-6, 2013
• Nanjo S, Yamada T, Nishihara H, Takeuchi S, Sano T, Nakagawa T, Ishikawa D, Zhao L, Ebi H, Yasumoto K, Matsumoto K, Yano S. : Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors. PLoS One 8:e84700, 2013
• Nakade J, Takeuchi S, Nakagawa T, Ishikawa D, Sano T, Nanjo S, Yamada T , Ebi H, Zhao Lu, Yasumoto K, Yonekura K, Yano S. : Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol 9:775-83, 2014
• Kenji Kita, Sachiko Arai, Akihiro Nishiyama, Hirokazu Taniguchi, Koji Fukuda, Rong Wang, Tadaaki Yamada, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Mitsutoshi Nakada, Kazuo Yasumoto, Yoshiharu Motoo, Takashi Murakami & Seiji Yano. : In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs. Cancer Medicine 2017; 6(12):2972–2983

主な研究受賞歴

• 金沢医学館記念医学賞
• 日本がん病態治療研究会　研究奨励賞
• 日本がん転移学会　優秀演題賞
• 日本消化器病学会　優秀演題賞
• 国際胃癌学会　優秀演題賞

研究を通しての産学連携　実績

2015年4月米国リリー社による “Innovation Day Japan” 開催（東京）
2016年6月米国リリー社との難治性胃がんの新規治療薬開発に関する共同研究契約締結

国立研究開発法人　日本医療研究開発機構（AMED）での研究　採択実績