Pathology and Laboratory Medicine
Outline
The Department of Pathology and Laboratory Medicine was established on September 1, 1974, when Kanazawa Medical University Hospital was opened. The original faculty members were Professor Terahata (also the head of the Central Clinical Laboratory), senior assistant professor Nagata (also the head of the Blood Transfusion Service), and assistant professor Teraoka (also the Central Clinical Laboratory chief technician). They were responsible for establishing and running the new Central Clinical Laboratory, which was equipped with a new, state of the art large analyzer. They spent several years preparing for the establishment of the department and getting the hospital work on track, and then built the foundation for the current Central Clinical Laboratory and Blood Center.
After Prof. Terahata retired in 1995, senior assistant professors Fukunaga and Hayase ran the department by themselves for six years. In 2001, Dr. Nojima, who transferred from Hokkaido University in 1994 to become the first professor of the hospital pathology division, became the Department Chair. In the same year, Assistant Professor Kurose joined the department and in 2007, Prof. Minato from Kanazawa University came to work in the department.
In July 2017, Professor Yamada, who came from Kagoshima University, became the Department Chair and Professor.
e-mail: clinpath@kanazawa-med.ac.jp
Faculty
Research Achievements
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Yamada S, Guo X.
Pathol Int. 2018 Feb;68(2):91-101. doi: 10.1111/pin.12634. Epub 2018 Jan 17.PMID: 29341349
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Guo X, Noguchi H, Ishii N, Homma T, Hamada T, Hiraki T, Zhang J, Matsuo K, Yokoyama S, Ishibashi H, Fukushige T, Kanekura T, Fujii J, Uramoto H, Tanimoto A, Yamada S.
Antioxid Redox Signal. 2019 Apr 1;30(10):1271-1284. doi: 10.1089/ars.2017.7426. Epub 2018 Jun 11.PMID: 29687726
Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
Zheng J, Guo X, Nakamura Y, Zhou X, Yamaguchi R, Zhang J, Ishigaki Y, Uramoto H, Yamada S.
Oxid Med Cell Longev. 2020 Dec 28;2020:8262730. doi: 10.1155/2020/8262730. eCollection 2020.PMID: 33456675
PRDX4 Improved Aging-Related Delayed Wound Healing in Mice.
Yamaguchi R, Guo X, Zheng J, Zhang J, Han J, Shioya A, Uramoto H, Mochizuki T, Yamada S.
J Invest Dermatol. 2021 Nov;141(11):2720-2729. doi: 10.1016/j.jid.2021.04.015. Epub 2021 May 21.PMID: 34029576
The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role.
Han J, Itoh T, Shioya A, Sakurai M, Oyama T, Kumagai M, Takamura H, Okuro M, Mukai T, Kitakata H, Inagaki M, Higashi M, Guo X, Yamada S.
Histol Histopathol. 2023 Dec;38(12):1415-1427. doi: 10.14670/HH-18-666. Epub 2023 Sep 27.PMID: 37787446