General and Digestive Surgery
Outline
[Main research contents]
1. Study on the effect of Sphingolipid on carcinogenesis, progression, and metastasis of colorectal cancer.
2. Study on effects of Sphingolipid on NAFLD and liver carcinogenesis.
3. Functional analysis of NANOG, ZFP57, imprinting gene in colorectal cancer, and malignant soft tissue tumor (sarcoma).
4. Study on the validity of function-preserving surgery based on gastric cancer sentinel lymph node navigation by fluorescent labeling.
5. Study on the use of intestinal immunity enhancement therapy for gastrointestinal cancer.
6. Study on preoperative chemotherapy for advanced gastric cancer.
7. Study on preoperative radio-chemotherapy for advanced esophageal cancer, advanced rectal cancer, and advanced pancreatic cancer.
8. Study on postoperative adjuvant chemotherapy for advanced colorectal cancer.
9. Studies on coagulation and fibrinolysis abnormalities in sepsis.
10. Study on the use of intestinal immunity enhancement and antiplatelet therapy in liver surgery, including liver transplantation.
[Main clinical fields]
Upper digestive surgery, Colorectal surgery, Hepatobiliary–pancreatic and splenic surgery, Abdominal hernia surgery, Abdominal malignant soft tissue tumor surgery, Obesity surgical treatment"
e-mail: gastsurg@kanazawa-med.ac.jp
Faculty
Research Achievements
- Miyata T, Shinden Y, Motoyama S, et al. Non-Alcoholic Fatty Liver Disease May Be a Risk Factor for Liver Metastasis After Radical Surgery for Colorectal Cancer: A Retrospective Study. J Gastrointest Cancer. 2024 Mar 19. doi: 10.1007/s12029-024-01042-6.
- Nakamura N, Kinami S, Kaida D, et al. Prognostic factors in T4b gastric cancer after surgery: A more balanced and sequential therapy for patients? J Cancer Res Ther. 20(1): 211-215, 2024.
- Kinami S, Kaida D, Okamoto K, et al. Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer. Oncol Lett. 2024 Jan 22;27(3):115. doi: 10.3892/ol.2024.14248.
- Okamoto K, Inaki N, Saito H, et al. Analysis of factors associated with operative difficulty in thoracoscopic esophageal cancer surgery in the left-decubitus position: a single-center retrospective study. BMC Surg. 2023 Aug 18;23(1):242. doi: 10.1186/s12893-023-02131-2.
- Kin R, Hoshi D, Fujita H, et al. Prognostic significance of p16, p21, and Ki67 expression at the invasive front of colorectal cancers. Pathol Int. 73(2): 81-90, 2023.
External Research Funding
- TAKAMURA H. Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture 2022; Basic research for the application of selective sphingomyelin synthase 2 inhibitor to the liver surgery.
- MIYATA T. Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture 2021; Research for new biomarkers of the sinusoid obstructive syndrome of liver focusing on platelet aggregation.
- TOMITA Y. Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture 2021; Suppression of colorectal cancer liver metastasis by inhibition of sphingomyelin synthase in fatty liver.
- NAKAMURA N. Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture 2021; Research for the effects of sphingolipids on non-alcoholic fatty liver disease-related liver carcinogenesis.
- OKAMOTO K. Grant-in-Aid for Scientific Research of the Ministry of Education, Science and Culture 2018; Fundamental studies on tumor regulation through cellular senescence of fibroblasts in the cancer microenvironment.