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December 6 (Sun)
4:00-6:30 pm Registration
6:00-8:00 pm Welcome Reception
December 7 (Mon) Day 1 
8:00-8:10 am Welcoming Comments by Peter F. Kador and Hiroshi Sasaki
8:10-9:50 am Platform Session 1: Cell Structure/Function
Moderators: Velia M. Fowler, Paul J. Donaldson
1. Velia M. Fowler: Actin cytoskeleton in lens architecture and mechanics
2. P. Vasantha Rao: Fiber cell membrane cytoskeletal scaffolding mechanisms and lens cytoarchitecture, biomechanics and transparency
3. Caitlin M. Logan: A critical role for N-cadherin in lens fiber cell elongation and tissue morphogenesis
4. Yuki Sugiyama: Is directed migration of the lens fibre cells led by guidance signals?
5. Paul J. Donaldson: Mapping the subcellular distribution of AQP0 and AQP5: implications for the water permeability of lens fiber cells
9:50-10:10 am Break
10:10-12:10 pm Platform Session 2: Lens Cell Survival and Aging
Moderators: Judith A. West-Mays, Shizuya Saika
1. Robb de Iongh: Lens proliferation and survival factors
2. Ichiro Masai: Cell division and cadherin-mediated adhesion regulate lens epithelial cell movement in zebrafish
3. Marjorie F. Lou: Glutaredoxin2 (Grx2) and aging
4. Allen Taylor: Lens fiber cell denucleation co-opts the Cdk1 mitotic machinery
5. Gabriel R. Cavalheiro: N-myc regulates mouse lens growth and differentiation in vivo
6. Noriaki Nagai: Hyperglycemia enhances the production of amyloid β1-42 in the lenses of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes
12:10-1:30 pm Lunch
1:30-3:15 pm Platform Session 3: Fiber Cell Differentiation and Environment ― dedicated to the memory of Dr. David Beebe ―
Moderators: Paul G. FitzGerald, Frank J. Lovicu
1. John McAvoy: Fibre differentiation ? where we have been and where we are going
2. Mikako Oka: Isolation of stem cells from lens epithelial cells and its environment for differentiation
3. Eric C. Beyer: Connexin23 is dispensable for lens transparency
4. Salil A. Lachke: Conserved RNA binding proteins in lens fiber differentiation
5. Frank J. Lovicu: Regulation of growth factor-induced lens fibre differentiation
3:15-3:35 pm Break
3:35-5:35 pm Platform Session 4: Oxidation and Disease
Moderators: Frank J. Giblin, Dhirendra P. Singh
1. Roger J. W. Truscott: Aging and the human lens
2. Renita M. Martis: Role of the cystine/glutamate antiporter in maintaining glutathione levels in ocular tissues
3. Bhavana Chhunchha: Nrf2 promotes lens epithelial cell death by enhancing oxidative stress through activation of Klf9-mediated repression of Prdx6
4. Claudio Bucolo: Small molecules to treat age-related eye diseases: a clue from activators of Nrf2-HO-1 antioxidant axis
5. Mitchell G. Nye-Wood: Oxidative stress induced changes to the optical properties of the bovine lens
6. Frank J. Giblin: Biphasic PARP-1 repair of DNA in human lens epithelial cells exposed to UVB light
6:00- pm Luau: Dinner
7:00- pm Luau: Show
December 8 (Tue) Day 2 
8:00-9:40 am Platform Session 5: Lens Cell Survival and Development
Moderators: John I. Clark, Steven Bassnett
1. Alan Shiels: Lens ER-stress response in MIP-mutant mice
2. Noboru Mizushima: Live imaging and molecular dissection of organelle degradation in the lens
3. Timothy F. Plageman, Jr.: Requirements for cellular folate during lens development
4. Steven Bassnett: Modeling lens growth in the mouse
5. Owen Lawrence: Investigation of zebrafish occhiolino as a model for human Alports syndrome
9:40-10:00 am Break
10:00-11:40 am Platform Session 6: Lens Genetics and Gene Expression
Moderators: Xiaohua Gong, Dorairajan Balasubramanian
1. Ales Cvekl: Evolutionary origins of Pax6 control of crystallin genes
2. Xin Zhang: The role of adaptor protein Crk and CrkL in lens development
3. Dorairajan Balasubramanian: For Want of a Nail: How the mutation R48H in human γC-crystallin hardly affects structure or stability, but is associated with pathology
4. Xiaohua Gong: Genetic variances of periaxin and CP49 manifest lens transparency and stiffness by affecting fiber cell morphogenesis
5. Yosuke Nakazawa: Effect of interaction between aquaporin 0 and filensin for functions of aquaporin 0
11:40-1:00 pm Lunch
1:00-2:20 pm Platform Session 7: Posterior Capsular Opacification I
Moderators: I. Michael Wormstone, Eri Kubo
1. I. Michael Wormstone: Growth factor restriction impedes progression of wound healing following cataract surgery; identification of VEGF as a putative therapeutic target
2. Eri Kubo: Gene expression profiling of lens epithelial cells in posterior capsular opacity and the role of decorin
3. Andrew J. O. Smith: Elucidating the role of αV integrin in TGFβ1 mediated fibrotic responses: implications for PCO
4. Rooban B. Nahomi: αB-crystallin is essential for the TGF-β2 mediated EMT of lens epithelial cells
2:20-2:35 pm Break
2:35-3:55 pm Platform Session 8: Posterior Capsular Opacification II
Moderators: Vladimir Bantseev, Yuka Okada
1. Yuka Okada: Matricelilar protein family modulation of TGFβ/Smad signaling in EMT
2. Yoshiki Miyata: Structure activity relationship study of novel synthesized flavones as matrix metalloproteinase inhibitors in lens epithelial cells
3. Vladimir Bantseev: Development of pseudophakic model in young non-human primates
4. Janice L. Walker: Mechanisms of fibrosis in a mock cataract surgery wound repair model
3:55-4:10 pm Break
4:10-6:20 pm Poster Oral Summaries
Moderators: John McAvoy
P1 Chen Maosheng: Operation for blunt ocular trauma, traumatic lens dislocation, secondary high pressure of eye (CASE REPORT)
P2 Rui Liu: The investigation surgical timing traumatic cataract with capsula broken and clinical effect of secondary intraocular lens implantation
P3 Koichiro Mukai: Experimental attempt to prevent posterior cataract opacification using hole-IOL
P4 Han Zhang: Comparison of iris-fixated foldable lens and scleral-fixated foldable lens implantation in eyes with insufficient capsular support
P5 Li Xingyu: Intraocular lens power calculation using IOLMaster and various formulas in Chinese population with axial length exceeding 30.00 mm
P6 Nao Nishida: Evaluation of light scattering in 4 types of hydrophobic acrylic intraocular lens
P7 Nobuyuki Ishikawa: Cataract surgery in pseudoexfoliation syndrome: impaired mydriasis and postoperative increment in intraocular pressure
P8 Kei Ichikawa: Estimation of the lens volume of normal eye from the ultrasound biomicroscope images
P9 Pingjun Chang: An optical section-assisted in vivo animal model for capsular bend evolution
P10 Tadahiko Tamura: Histopathological analysis of the ratio of intraocular lens with cellular deposits
P11 Wenjuan Wan: Management of capsular contraction after complicated cataract surgeries
P12 Xin Liu: Surgical technique comparison of a limbal versus pars plana approach using the microincision vitrectomy system for removal of congenital cataracts with primary intraocular lens implantation
P13 Norihiro Mita: Higher-order aberrations in Japanese eyes with cataracts and eyes with aspherical intraocular lenses
P14 Eri Shibuya: Influence on visual function by high-order aberration, forward and backward light scattering in eyes with nuclear opacity
P15 Natsuko Hatsusaka: Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4 years post-exposure
P16 Xixia Ding: The repeatability assessment of three-dimensional capsule-intraocular lens complex measurements by means of high-speed swept-source optical coherence tomography
P17 Zhiying Kong: Visualizing fiber cells in a whole living lens in real-time
P18 Rijo Hayashi: The changes of hydrogen peroxide in aqueous humor and glutathione peroxidase in the anterior capsule after intake of a lutein-containing antioxidant supplement in a gender-differentiated analysis
P19 Nobuyuki Kanemaki: The capsular thickness and cells attached to the anterior lens capsules in dogs with mature cataract
P20 Mayuko Eguchi: Comparison of free radical scavenging activities between original and generic anti-cataract eye drops
P21 Hamdy Abdelkader: Anti-cataractogenic effect of L-carnosine: metabolomics, proteomic and cytotoxicity investigation
P22 Hirotaka Hashimoto: The effect of astaxanthin on VEGF levels and peroxidation reactions in the aqueous humor
P23 Hai Yan Zhou: The betaine-homocysteine S-methyltransferase 1 (BHMT1) involved in human age-related nuclear cataracts
P24 Andre Cleaver: Inverse finite element analysis of mouse lens compression for determining elastic moduli
P25 Shinsuke Shibata: Human age related cataract and decorin: correlations among opacity severity, age and decorin expression
P26 Teppei Shibata: Suppression of injury-induced epithelial-mesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9
P27 Keke Zhang: The inhibitory effect of Zebularine on the posterior capsule opacification after phacoemulsification in a rabbit model induced by transforming growth factor-beta 2
P28 Niklaus H. Mueller: Mutation of phosphorylation sites in αA-crystallin does not impair chaperone function or anti-apoptotic function
P29 Wiktor Stopka: αA-crystallin point mutations affect different types of F-actin networks
P30 Song Wang: Screening and verification of genes and proteins involved in oxidative damage on human lens epithelial cells cultured in physiological hypoxia
P31 Rosana Mesa: Next generation sequencing of somatic variants in human lens epithelial cell DNA: a feasibility study
P32 Kumarasamy Anbarasu: Structural and functional modifications of arginine mutation in αA-crystallin
P33 Hiromi Osada: Identification of UVB responsive genes in in vivo mouse lens by cDNA microarray
P34 Yingying Yu: Effect of UV-B irradiation on the secondary structural properties of α-crystallin pior to its chaperone-like activity
P35 Eddie Wang: Gja8 (Cx50) is important for ball and socket formation in differentiating lens fibers
P36 Catherine Cheng: Tropomodulin 1 regulation of actin is required for the formation of large paddle protrusions between mature lens fiber cells
P37 Jian Zhou: Effects of activation of Src-family tyrosine kinases on human LEC apoptosis and EMT under high glucose environment
P38 J. Mark Petrash: Induction of inflammatory mediators by elevated aldose reductase gene expression in the lens
P39 Chun-hong Xia: Identify novel genetic modifiers on mouse chromosome 2 for cataractogenesis
6:20-6:50 pm Poster Viewing I
December 9 (Wed) Day 3 
8:00-8:30 am Poster Viewing II
8:30-10:10 am Platform Session 9: Cataract Surgery
Moderators: Hiroyuki Matsushima, Daijiro Kurosaka
1. Norihito Gotoh: Corneal and conjunctival damages during cataract surgery
2. Mayumi Nagata: Posterior capsular opacification and anterior capsule contraction
3. Shinichiro Kobayakawa: Tass and infectious endophthalmitis
4. Junya Kizawa: Differences in the behavior of?various OVDs in torsional phacoemulsification
5. Toyoaki Matsuura: Evaluation of accommodation at hydrogel lens refilling
10:10-10:30 am Break
10:30-12:30 pm Platform Session 10: Regulation of Fiber Differentiation
Moderators: David W. Li, Mikako Oka
1. Kenta Wada: Identification of genetic mutation of the transcription factor encoding genes for lens development in mice
2. Yingwei Mao: A critical role of an exon junction complex (EJC) factor in regulation of embryonic eye development
3. Fu Shang: Lens fiber regeneration after cataract surgery
4. David W. Li: Regulation of lens differentiation by the tumor suppressor, p53
5. Ling Wang: AlphaA-crystallin negatively regulates p53-dependent apoptosis through modulation of ATM/ATR kinases
6. Michael D. O'Connor: Insights into lens biology, anti-cataract drug screening and lens regeneration using a new, large-scale source of human lens cells
12:30- pm Box Lunch, Free Afternoon
Golf Tournament
December 10 (Thu) Day 4 
8:00-10:00 am Platform Session 11: Cell Communication and Transport I
Moderators: Woo-Kuen Lo, Thomas W. White
1. Kevin L. Schey: Structural and functional studies of lens aquaporins
2. James B. Fields: Phosphorylation of aquaporin zero and the calmodulin interaction
3. Viviana M. Berthoud: Cx50D47A causes lens ER stress
4. Lisa Ebihara: Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cells
5. Thomas W. White: Cx43 and Cx50 channels have differential permeability to cAMP, IP3 and Ca2+
6. Woo-Kuen Lo: AQP0 and N-cadherin/adherens junctions play a cooperative role for the integrity of interlocking domains and transparency of the lens
10:00-10:20 am Break
10:20-12:20 pm Platform Session 12: Cataract Pathogenesis and Treatment
Moderators: Peter F. Kador, Marc Kantorow
1. Kang Zhang: Role of lanosterol in reducing protein aggregation in cataracts
2. M. Joseph Costello: Role of autophagy in formation of the lens organelle free zone
3. Marc Kantorow: Lens epithelial cell mitochondrial translocation and protection by αB-crystallin prevents protein oxidation and apoptosis resulting from lens oxidative stress and UV-light exposures
4. Robert J. Munger: KinostatTM prevents cataracts in diabetic dogs
5. Per G. Söderberg: Protective effect of caffeine against UVR induced oxidative stress in the lens
6. Peter F. Kador: In vitro lens culture studies can identify potential cataractogenic mechanisms and identify anticataract drugs
12:20-1:40 pm Lunch
1:40-3:40 pm Platform Session 13: Age-Related Changes in Proteins and Lipids
Moderators: Juliet A. Moncaster, Kirsten J. Lampi
1. Juliet A. Moncaster: In vivo assessment of molecular aging by quasi-elastic light scattering in human lens
2. Kirsten J. Lampi: Aggregation of lens homogenates by the deamidation mutant βB2 Q70E/Q162E
3. J. Samuel Zigler, Jr.: βA3/A1-crystallin: Possible function in the RPE
4. Larry L. David: Mass spectrometry based accurate quantitation of crystallins in human lens aggregates using recombinant crystallin standards
5. Masaaki Sugiyama: Subunit kinetics in α-crystallins
6. Barbara Pierscionek: Ageing variations in the refractive index of human lenses
3:40-4:00 pm Break
4:00-5:40 pm Platform Session 14: Crystallins: Form and Function
Moderators: Noriko Fujii, Vincent M. Monnier
1. Ram H. Nagaraj: Lysine acylation alters structure and function of human lens αB-crystallin
2. Vincent M. Monnier: Molecular basis for lens crystallin denaturation and precipitation by vitamin C oxidation products
3. Takumi Takata: Isomerization of Asp residues is different between monomer and hetero-polymer of alpha-crystallin in aged human lens
4. Noriko Fujii: The spontaneous breaking of homochirality in lens crystallins from elderly donors
5. Chitra Kannabiran: Mechanism of cataract induced by splice mutation in beta A3/A1-crystallin
6:10-7:10 pm Kinoshita Lecture
Robert C. Augusteyn
7:10-7:40 pm Cocktails
7:40- pm Banquet
December 11 (Fri) Day 5 
8:00-10:00 am Platform Session 15: Clinical Study and Lens Imaging
Moderators: Hiroshi Sasaki, Hong Yan
1. Xiangjia Zhu: Molecular inflammation in contralateral eye after the first eye cataract surgery
2. Matthew A. Reilly: Bio-chemo-mechanical model of lens aging
3. Stephan Reiß: Non-invasive determination of the tissue properties of the eye lens by Brillouin spectroscopy
4. Oliver Stachs: High spatial resolution in vivo magnetic resonance imaging of the human eye at 7.0 Tesla
5. Hiroshi Sasaki: Myopia and related factors in Tanzanian adults
6. Robert C. Augusteyn: The human lens nucleus
10:00-10:20 am Break
10:20-12:00 pm Platform Session 16: Cell Communication and Transport II
Moderators: Richard T. Mathias, Marjorie F. Lou
1. Xingjun Fan: Lenticular GSH homeostasis and its therapeutic potential
2. Nicholas A. Delamere: TRPV4 ion channels are part of a remote control mechanism for tyrosine kinases and Na,K-ATPase in lens epithelium
3. Ehsan Vaghefi: Real-time monitoring the physiological optics of the lens
4. Irene Vorontsova: Aqp0a and Aqp0b expression in the zebrafish lens
5. James E. Hall: An arginine rich loop plays a critical role in the modulation of AQP0 water permeability
12:00-12:10 pm Closing Remark by Peter F. Kador and Hiroshi Sasaki
12:10- pm Lunch
Department of Ophthalmology, Kanazawa Medical University
Phone number: +81 76-286-2211 (ext. 3415)
E-mail: icl2015@kanazawa-med.ac.jp
Copyright(C): International Conference on the Lens 2015 All Rights Reserved.