December 6 (Sun) |
4:00-6:30 pm |
Registration |
6:00-8:00 pm |
Welcome Reception |
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December 7 (Mon) Day 1 |
8:00-8:10 am |
Welcoming Comments by Peter F. Kador and Hiroshi Sasaki |
8:10-9:50 am |
Platform Session 1: Cell Structure/Function |
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Moderators: Velia M. Fowler, Paul J. Donaldson
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1. |
Velia M. Fowler: Actin cytoskeleton in lens architecture and mechanics |
2. |
P. Vasantha Rao: Fiber cell membrane cytoskeletal scaffolding mechanisms
and lens cytoarchitecture, biomechanics and transparency |
3. |
Caitlin M. Logan: A critical role for N-cadherin in lens fiber cell elongation
and tissue morphogenesis |
4. |
Yuki Sugiyama: Is directed migration of the lens fibre cells led by guidance
signals? |
5. |
Paul J. Donaldson: Mapping the subcellular distribution of AQP0 and AQP5:
implications for the water permeability of lens fiber cells |
9:50-10:10 am |
Break |
10:10-12:10 pm |
Platform Session 2: Lens Cell Survival and Aging |
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Moderators: Judith A. West-Mays, Shizuya Saika
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1. |
Robb de Iongh: Lens proliferation and survival factors |
2. |
Ichiro Masai: Cell division and cadherin-mediated adhesion regulate lens
epithelial cell movement in zebrafish |
3. |
Marjorie F. Lou: Glutaredoxin2 (Grx2) and aging |
4. |
Allen Taylor: Lens fiber cell denucleation co-opts the Cdk1 mitotic machinery |
5. |
Gabriel R. Cavalheiro: N-myc regulates mouse lens growth and differentiation
in vivo |
6. |
Noriaki Nagai: Hyperglycemia enhances the production of amyloid β1-42 in the lenses of Otsuka Long-Evans Tokushima Fatty rats, a model of human
type 2 diabetes |
12:10-1:30 pm |
Lunch |
1:30-3:15 pm |
Platform Session 3: Fiber Cell Differentiation and Environment ― dedicated
to the memory of Dr. David Beebe ― |
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Moderators: Paul G. FitzGerald, Frank J. Lovicu
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1. |
John McAvoy: Fibre differentiation ? where we have been and where we are
going |
2. |
Mikako Oka: Isolation of stem cells from lens epithelial cells and its
environment for differentiation |
3. |
Eric C. Beyer: Connexin23 is dispensable for lens transparency |
4. |
Salil A. Lachke: Conserved RNA binding proteins in lens fiber differentiation |
5. |
Frank J. Lovicu: Regulation of growth factor-induced lens fibre differentiation |
3:15-3:35 pm |
Break |
3:35-5:35 pm |
Platform Session 4: Oxidation and Disease |
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Moderators: Frank J. Giblin, Dhirendra P. Singh
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1. |
Roger J. W. Truscott: Aging and the human lens |
2. |
Renita M. Martis: Role of the cystine/glutamate antiporter in maintaining
glutathione levels in ocular tissues |
3. |
Bhavana Chhunchha: Nrf2 promotes lens epithelial cell death by enhancing
oxidative stress through activation of Klf9-mediated repression of Prdx6 |
4. |
Claudio Bucolo: Small molecules to treat age-related eye diseases: a clue
from activators of Nrf2-HO-1 antioxidant axis |
5. |
Mitchell G. Nye-Wood: Oxidative stress induced changes to the optical properties
of the bovine lens |
6. |
Frank J. Giblin: Biphasic PARP-1 repair of DNA in human lens epithelial
cells exposed to UVB light |
|
|
6:00- pm |
Luau: Dinner |
7:00- pm |
Luau: Show |
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December 8 (Tue) Day 2 |
8:00-9:40 am |
Platform Session 5: Lens Cell Survival and Development |
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Moderators: John I. Clark, Steven Bassnett
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1. |
Alan Shiels: Lens ER-stress response in MIP-mutant mice |
2. |
Noboru Mizushima: Live imaging and molecular dissection of organelle degradation
in the lens |
3. |
Timothy F. Plageman, Jr.: Requirements for cellular folate during lens
development |
4. |
Steven Bassnett: Modeling lens growth in the mouse |
5. |
Owen Lawrence: Investigation of zebrafish occhiolino as a model for human Alports syndrome |
9:40-10:00 am |
Break |
10:00-11:40 am |
Platform Session 6: Lens Genetics and Gene Expression |
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Moderators: Xiaohua Gong, Dorairajan Balasubramanian
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1. |
Ales Cvekl: Evolutionary origins of Pax6 control of crystallin genes |
2. |
Xin Zhang: The role of adaptor protein Crk and CrkL in lens development |
3. |
Dorairajan Balasubramanian: For Want of a Nail: How the mutation R48H in
human γC-crystallin hardly affects structure or stability, but is associated
with pathology |
4. |
Xiaohua Gong: Genetic variances of periaxin and CP49 manifest lens transparency
and stiffness by affecting fiber cell morphogenesis |
5. |
Yosuke Nakazawa: Effect of interaction between aquaporin 0 and filensin
for functions of aquaporin 0 |
11:40-1:00 pm |
Lunch |
1:00-2:20 pm |
Platform Session 7: Posterior Capsular Opacification I |
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Moderators: I. Michael Wormstone, Eri Kubo
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1. |
I. Michael Wormstone: Growth factor restriction impedes progression of
wound healing following cataract surgery; identification of VEGF as a putative
therapeutic target |
2. |
Eri Kubo: Gene expression profiling of
lens epithelial cells in posterior capsular opacity and the role of decorin |
3. |
Andrew J. O. Smith: Elucidating the role of αV integrin in TGFβ1 mediated
fibrotic responses: implications for PCO |
4. |
Rooban B. Nahomi: αB-crystallin is essential for the TGF-β2 mediated EMT
of lens epithelial cells |
2:20-2:35 pm |
Break |
2:35-3:55 pm |
Platform Session 8: Posterior Capsular Opacification II |
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Moderators: Vladimir Bantseev, Yuka Okada
|
1. |
Yuka Okada: Matricelilar protein family modulation of TGFβ/Smad signaling
in EMT |
2. |
Yoshiki Miyata: Structure activity relationship study of novel synthesized
flavones as matrix metalloproteinase inhibitors in lens epithelial cells |
3. |
Vladimir Bantseev: Development of pseudophakic model in young non-human
primates |
4. |
Janice L. Walker: Mechanisms of fibrosis in a mock cataract surgery wound
repair model |
3:55-4:10 pm |
Break |
4:10-6:20 pm |
Poster Oral Summaries |
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Moderators: John McAvoy
|
P1 |
Chen Maosheng: Operation for blunt ocular trauma, traumatic lens dislocation,
secondary high pressure of eye (CASE REPORT) |
P2 |
Rui Liu: The investigation surgical timing traumatic cataract with capsula
broken and clinical effect of secondary intraocular lens implantation |
P3 |
Koichiro Mukai: Experimental attempt to prevent posterior cataract opacification
using hole-IOL |
P4 |
Han Zhang: Comparison of iris-fixated foldable lens and scleral-fixated
foldable lens implantation in eyes with insufficient capsular support |
P5 |
Li Xingyu: Intraocular lens power calculation using IOLMaster and various
formulas in Chinese population with axial length exceeding 30.00 mm |
P6 |
Nao Nishida: Evaluation of light scattering in 4 types of hydrophobic acrylic
intraocular lens |
P7 |
Nobuyuki Ishikawa: Cataract surgery in pseudoexfoliation syndrome: impaired
mydriasis and postoperative increment in intraocular pressure |
P8 |
Kei Ichikawa: Estimation of the lens volume of normal eye from the ultrasound
biomicroscope images |
P9 |
Pingjun Chang: An optical section-assisted in vivo animal model for capsular bend evolution |
P10 |
Tadahiko Tamura: Histopathological analysis of the ratio of intraocular
lens with cellular deposits |
P11 |
Wenjuan Wan: Management of capsular contraction after complicated cataract
surgeries |
P12 |
Xin Liu: Surgical technique comparison of a limbal versus pars plana approach
using the microincision vitrectomy system for removal of congenital cataracts
with primary intraocular lens implantation |
P13 |
Norihiro Mita: Higher-order aberrations in Japanese eyes with cataracts
and eyes with aspherical intraocular lenses |
P14 |
Eri Shibuya: Influence on visual function by high-order aberration, forward
and backward light scattering in eyes with nuclear opacity |
P15 |
Natsuko Hatsusaka: Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4 years post-exposure |
P16 |
Xixia Ding: The repeatability assessment of three-dimensional capsule-intraocular
lens complex measurements by means of high-speed swept-source optical coherence
tomography |
P17 |
Zhiying Kong: Visualizing fiber cells in a whole living lens in real-time |
P18 |
Rijo Hayashi: The changes of hydrogen peroxide in aqueous humor and glutathione
peroxidase in the anterior capsule after intake of a lutein-containing
antioxidant supplement in a gender-differentiated analysis |
P19 |
Nobuyuki Kanemaki: The capsular thickness and cells attached to the anterior
lens capsules in dogs with mature cataract |
P20 |
Mayuko Eguchi: Comparison of free radical scavenging activities between
original and generic anti-cataract eye drops |
P21 |
Hamdy Abdelkader: Anti-cataractogenic effect of L-carnosine: metabolomics,
proteomic and cytotoxicity investigation |
P22 |
Hirotaka Hashimoto: The effect of astaxanthin on VEGF levels and peroxidation
reactions in the aqueous humor |
P23 |
Hai Yan Zhou: The betaine-homocysteine S-methyltransferase 1 (BHMT1) involved
in human age-related nuclear cataracts |
P24 |
Andre Cleaver: Inverse finite element analysis of mouse lens compression
for determining elastic moduli |
P25 |
Shinsuke Shibata: Human age related cataract and decorin: correlations
among opacity severity, age and decorin expression |
P26 |
Teppei Shibata: Suppression of injury-induced epithelial-mesenchymal transition
in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9 |
P27 |
Keke Zhang: The inhibitory effect of Zebularine on the posterior capsule
opacification after phacoemulsification in a rabbit model induced by transforming
growth factor-beta 2 |
P28 |
Niklaus H. Mueller: Mutation of phosphorylation sites in αA-crystallin
does not impair chaperone function or anti-apoptotic function |
P29 |
Wiktor Stopka: αA-crystallin point mutations affect different types of
F-actin networks |
P30 |
Song Wang: Screening and verification of genes and proteins involved in
oxidative damage on human lens epithelial cells cultured in physiological
hypoxia |
P31 |
Rosana Mesa: Next generation sequencing of somatic variants in human lens
epithelial cell DNA: a feasibility study |
P32 |
Kumarasamy Anbarasu: Structural and functional modifications of arginine
mutation in αA-crystallin |
P33 |
Hiromi Osada: Identification of UVB responsive genes in in vivo mouse lens by cDNA microarray |
P34 |
Yingying Yu: Effect of UV-B irradiation on the secondary structural properties
of α-crystallin pior to its chaperone-like activity |
P35 |
Eddie Wang: Gja8 (Cx50) is important for ball and socket formation in differentiating
lens fibers |
P36 |
Catherine Cheng: Tropomodulin 1 regulation of actin is required for the
formation of large paddle protrusions between mature lens fiber cells |
P37 |
Jian Zhou: Effects of activation of Src-family tyrosine kinases on human
LEC apoptosis and EMT under high glucose environment |
P38 |
J. Mark Petrash: Induction of inflammatory mediators by elevated aldose
reductase gene expression in the lens |
P39 |
Chun-hong Xia: Identify novel genetic modifiers on mouse chromosome 2 for
cataractogenesis |
6:20-6:50 pm |
Poster Viewing I |
|
December 9 (Wed) Day 3 |
8:00-8:30 am |
Poster Viewing II |
8:30-10:10 am |
Platform Session 9: Cataract Surgery |
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Moderators: Hiroyuki Matsushima, Daijiro Kurosaka
|
1. |
Norihito Gotoh: Corneal and conjunctival damages during cataract surgery |
2. |
Mayumi Nagata: Posterior capsular opacification and anterior capsule contraction |
3. |
Shinichiro Kobayakawa: Tass and infectious endophthalmitis |
4. |
Junya Kizawa: Differences in the behavior of?various OVDs in torsional
phacoemulsification |
5. |
Toyoaki Matsuura: Evaluation of accommodation at hydrogel lens refilling |
10:10-10:30 am |
Break |
10:30-12:30 pm |
Platform Session 10: Regulation of Fiber Differentiation |
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Moderators: David W. Li, Mikako Oka
|
1. |
Kenta Wada: Identification of genetic mutation of the transcription factor
encoding genes for lens development in mice |
2. |
Yingwei Mao: A critical role of an exon junction complex (EJC) factor in
regulation of embryonic eye development |
3. |
Fu Shang: Lens fiber regeneration after cataract surgery |
4. |
David W. Li: Regulation of lens differentiation by the tumor suppressor,
p53 |
5. |
Ling Wang: AlphaA-crystallin negatively regulates p53-dependent apoptosis
through modulation of ATM/ATR kinases |
6. |
Michael D. O'Connor: Insights into lens biology, anti-cataract drug screening
and lens regeneration using a new, large-scale source of human lens cells |
12:30- pm |
Box Lunch, Free Afternoon |
|
Golf Tournament |
|
December 10 (Thu) Day 4 |
8:00-10:00 am |
Platform Session 11: Cell Communication and Transport I |
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Moderators: Woo-Kuen Lo, Thomas W. White
|
1. |
Kevin L. Schey: Structural and functional studies of lens aquaporins |
2. |
James B. Fields: Phosphorylation of aquaporin zero and the calmodulin interaction |
3. |
Viviana M. Berthoud: Cx50D47A causes lens ER stress |
4. |
Lisa Ebihara: Cx46 hemichannels contribute to the sodium leak conductance
in lens fiber cells |
5. |
Thomas W. White: Cx43 and Cx50 channels have differential permeability
to cAMP, IP3 and Ca2+ |
6. |
Woo-Kuen Lo: AQP0 and N-cadherin/adherens junctions play a cooperative
role for the integrity of interlocking domains and transparency of the
lens |
10:00-10:20 am |
Break |
10:20-12:20 pm |
Platform Session 12: Cataract Pathogenesis and Treatment |
|
Moderators: Peter F. Kador, Marc Kantorow
|
1. |
Kang Zhang: Role of lanosterol in reducing protein aggregation in cataracts |
2. |
M. Joseph Costello: Role of autophagy in formation of the lens organelle
free zone |
3. |
Marc Kantorow: Lens epithelial cell mitochondrial translocation and protection
by αB-crystallin prevents protein oxidation and apoptosis resulting from
lens oxidative stress and UV-light exposures |
4. |
Robert J. Munger: KinostatTM prevents cataracts in diabetic dogs |
5. |
Per G. Söderberg: Protective effect of caffeine against UVR induced oxidative
stress in the lens |
6. |
Peter F. Kador: In vitro lens culture studies can identify potential cataractogenic mechanisms
and identify anticataract drugs |
12:20-1:40 pm |
Lunch |
1:40-3:40 pm |
Platform Session 13: Age-Related Changes in Proteins and Lipids |
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Moderators: Juliet A. Moncaster, Kirsten J. Lampi
|
1. |
Juliet A. Moncaster: In vivo assessment of molecular aging by quasi-elastic light scattering in human
lens |
2. |
Kirsten J. Lampi: Aggregation of lens homogenates by the deamidation mutant
βB2 Q70E/Q162E |
3. |
J. Samuel Zigler, Jr.: βA3/A1-crystallin: Possible function in the RPE |
4. |
Larry L. David: Mass spectrometry based accurate quantitation of crystallins
in human lens aggregates using recombinant crystallin standards |
5. |
Masaaki Sugiyama: Subunit kinetics in α-crystallins |
6. |
Barbara Pierscionek: Ageing variations in the refractive index of human
lenses |
3:40-4:00 pm |
Break |
4:00-5:40 pm |
Platform Session 14: Crystallins: Form and Function |
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Moderators: Noriko Fujii, Vincent M. Monnier
|
1. |
Ram H. Nagaraj: Lysine acylation alters structure and function of human
lens αB-crystallin |
2. |
Vincent M. Monnier: Molecular basis for lens crystallin denaturation and
precipitation by vitamin C oxidation products |
3. |
Takumi Takata: Isomerization of Asp residues is different between monomer
and hetero-polymer of alpha-crystallin in aged human lens |
4. |
Noriko Fujii: The spontaneous breaking of homochirality in lens crystallins
from elderly donors |
5. |
Chitra Kannabiran: Mechanism of cataract induced by splice mutation in
beta A3/A1-crystallin |
|
|
6:10-7:10 pm |
Kinoshita Lecture |
|
Robert C. Augusteyn
|
7:10-7:40 pm |
Cocktails |
7:40- pm |
Banquet |
|
December 11 (Fri) Day 5 |
8:00-10:00 am |
Platform Session 15: Clinical Study and Lens Imaging |
|
Moderators: Hiroshi Sasaki, Hong Yan
|
1. |
Xiangjia Zhu: Molecular inflammation in contralateral eye after the first
eye cataract surgery |
2. |
Matthew A. Reilly: Bio-chemo-mechanical model of lens aging |
3. |
Stephan Reiß: Non-invasive determination of the tissue properties of the
eye lens by Brillouin spectroscopy |
4. |
Oliver Stachs: High spatial resolution in vivo magnetic resonance imaging of the human eye at 7.0 Tesla |
5. |
Hiroshi Sasaki: Myopia and related factors in Tanzanian adults |
6. |
Robert C. Augusteyn: The human lens nucleus |
10:00-10:20 am |
Break |
10:20-12:00 pm |
Platform Session 16: Cell Communication and Transport II |
|
Moderators: Richard T. Mathias, Marjorie F. Lou
|
1. |
Xingjun Fan: Lenticular GSH homeostasis and its therapeutic potential |
2. |
Nicholas A. Delamere: TRPV4 ion channels are part of a remote control mechanism
for tyrosine kinases and Na,K-ATPase in lens epithelium |
3. |
Ehsan Vaghefi: Real-time monitoring the physiological optics of the lens |
4. |
Irene Vorontsova: Aqp0a and Aqp0b expression in the zebrafish lens |
5. |
James E. Hall: An arginine rich loop plays a critical role in the modulation
of AQP0 water permeability |
12:00-12:10 pm |
Closing Remark by Peter F. Kador and Hiroshi Sasaki |
12:10- pm |
Lunch |
|
|
Depart |